INHIBITORY EFFECT OF LUTEOLIN-7-METHYL ETHER ON ESTROGEN BIOSYNTHESIS IN HUMAN OVARIAN GRANULOSA CELLS VIA AROMATASE SUPPRESSION

Abstract

Estrogens play a crucial role in breast development and various

physiological processes. A key enzyme in estrogen biosynthesis is aromatase, which

catalyzes one of the final steps in this process. In humans, aromatase expression is

regulated by tissue-specific promoters, with the primary site of estrogen synthesis in

premenopausal women being the ovaries, where its expression is driven by the

activation of a proximal promoter